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An ancient prophecy foretells that the world would end on 21 December 2012 . . .
Deep in the jungles of Central America, an indigenous man discovers a unique and priceless treasure - a beautifully painted codex that has survived for centuries within the ruins of an undiscovered ancient Maya city. Knowing that this rare artifact could be worth millions, the looter smuggles it into the US - but unbeknownst to him, he has brought something far more dangerous across the border . . .
In the first week of December 2012, the codex finds its way into the hands of the Antiquities Curator of the Getty Museum, Chel Manu, the world authority on ancient Mayan inscriptions. She is torn between her duty to alert the authorities and this once in a lifetime chance to translate the codex herself.
Meanwhile - in an LA hospital, an unidentified man is dying of Fatal Insomnia, a rare and highly infectious neurological disease. The patient speaks only in a garbled Mayan dialect - and Chel Manu is called in to interpret his dying words . . . just as countless others in the city begin to show signs of infection. Within days the world seems to be unravelling, hurtling towards the prophesied apocalypse . . . and deciphering the codex is the only hope for humanity . . .